![]() The investigation is focused on a number of Trump properties, including several that came up during Mr. Trump had overstated the value of his assets in financial statements when seeking bank loans and had understated them to reduce real estate taxes. James began her inquiry last year after the president’s former personal lawyer, Michael D. James is scrutinizing.Įric Trump reacted to the ruling by assailing the attorney general’s investigation as “a continued political vendetta.” Nonetheless, he added, “since I previously agreed to appear for an interview, I will do so as scheduled.” ![]() Justice Engoron also ordered the Trump Organization and several related entities and lawyers to turn over records connected to four of the properties that Ms. Trump cites no authority in support of his request, and in any event, neither petitioner, nor this court, is bound by timelines of the national election.” “This court finds that application unpersuasive,” the judge said from the bench after a two-hour hearing on Sept. Engoron of State Supreme Court in Manhattan rejected those arguments and ordered Eric Trump to sit for a deposition no later than Oct.
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![]() ![]() Herceptin has been shown to synergistically interact with both doxorubicin and paclitaxel, though cardiotoxicity risk is increased in combination therapy ( Pegram et al., 2000). There are a number of examples of clinical synergy in the area of cancer treatment, often established between established chemotherapy agents and agents representing other classes. If two drugs act synergistically, lower doses of each drug could potentially be used which could allow for less adverse effects while still provided the desired outcome, such as cancer cell death. This potentially allows for maximizing the therapeutic effect while minimizing the adverse effect, or side effects, upon being treated with a given drug regimen ( Greco et al., 1996 Foucquier and Guedj, 2015). ![]() This is particularly true in cancer treatment. This is because many diseases require treatment that consists of “cocktails,” or mixtures of various drugs taken at once. Synergy is most often defined in relation to the realms of pharmacology and medicine. Unfortunately, in practice, it is far from that simple to quantify such interactions. Now, going back to the 1 + 0 = 2 analogy ( Berthoud, 2013 Geary, 2013), it can be asserted that there is a synergistic interaction occurring. Synergy is commonly defined as the effect of two or more agents working in combination that is greater than the expected additive effect of said agents ( Greco et al., 1996). However, that paradigm is a very basic analogy for understanding synergist interactions, or synergy. So, it's very counterintuitive to say 1 + 0 = 2, 0 + 0 = 1, or even 1 + 1 = 0. The idea that 1 + 1 = 2 is not novel and virtually agreed upon and understood throughout various academic disciplines and even different cultures around the world. Finally, we describe how methods development and terminology have developed among disciplines outside of biomedicine and pharmacology, to synthesize the literature for readers. We also discuss advantages and limitations to each method, with a focus on the Chou-Talalay Combination Index method. We then review the most common methodology for detection and quantification of synergy, including the two most prominent reference models for describing additive interactions: Loewe Additivity and Bliss Independence. In this review, we first discuss the various terminology surrounding the idea of synergy, providing a comprehensive list of terms defined across numerous disciplines. However, the idea of synergy is not limited to only the biomedical realm and these ideas have developed across many different disciplines, as well. As complex diseases, especially cancer, are being treated with various drug cocktails, understanding the interactions among these drugs is increasingly vital to ensuring successful treatment regimens. The idea of synergistic interactions between drugs and chemicals has been an important issue in the biomedical world for over a century. 3Department of Statistics, North Carolina State University, Raleigh, NC, USA. ![]()
The full code in action can be found on Github. my_deploy_user: slavko my_deploy_authorized_keys: - "~/.ssh/id_rsa.pub" # revise port list for your use, consider securing by custom_ufw_rules_allow_from_hosts custom_ports_allow: - The full code in action More configuration options are available in role itself, but are out of scope for current the example. For example, we will use 22 SSH 500/4500 - Softether with IPSec 1194 - OpenVPN 1723 - PPTP
Since the entire project is locally stored and accessible to one programmer or researcher, any collaborative effort will be extremely difficult, and require manual duplication and syncing of the project with other developers. With this primitive method of project version control, it is not clear what the main differences between different versions of the project are, unless a very detailed documentation is provided along with each version detailing the differences between the current, its ancestor (i.e., the previous version of the project) and its descendant (i.e., the next version of the project), or parallel independent versions of the project (i.e., the project branches). However, since this is practically impossible, the programmer or the researcher has to either skip documenting all minor improvements and therefore, lose track of detailed changes in the code, or otherwise, worsen the first caveat mentioned above, by generating more and more redundant copies of the same codes and data for the sake of keeping track of all minor stages of the development. This means that in order to keep track of every minor stage of the program development, one has to create a new complete copy of the project, with its own dedicated directory. In professional programming, all minor developments and changes to a project must be tracked and well-documented (only the major versions of the project (called deliverable in programming terminology) are supposed to be available to non-developers or customers. ![]() Difficulty in tracking minor developments in the project.Using this method, it is easy to forget which directory you are in, and to accidentally write to the wrong file or to mistakenly overwrite files you did not mean to. High risk of errors and irreversible mistakes.So, there is a lot of code and data redundancy in using such an approach to keeping track of your project’s version history. But, each one has its own dedicated separate folder. Obviously, the new version of your project will have a lot in common with the previous version. Data redundancy and storage inefficiencyĮvery time you want to develop your existing project and take it to the next level, you have to make a whole copy of the last version of your project to start the new development (i.e., the next version of your project). ![]() Obviously, tracking minor development stages of the project leading to each of the deliverables would be a very difficult task with such project management method.Ĭlearly, there are many disadvantages and caveats with maintaining the structure of your project and codes similar to the content of the above figure: Each folder contains one version of the project and its corresponding codes and results at a given time (i.e., one deliverable). ![]() The figure shows part of the content of a directory dedicated to a research project. Back in the early years of my graduate studies when I started scientific research and programming, the directory containing my first project looked something like the following figure.Īn example of bad coding style and poor project maintenance. ![]() ![]() Make sure you download the Studio version, not the free version. To activate DaVinci Resolve Studio 16 with a serial key, you need to follow these steps:ĭownload and install DaVinci Resolve Studio 16 from the Blackmagic Design website. How to Activate DaVinci Resolve Studio 16 with a Serial Key We will also show you how to create and export a DCP using Easy DCP in DaVinci Resolve Studio 16. In this article, we will show you how to activate DaVinci Resolve Studio 16 and Easy DCP with a serial key and a license, respectively. The Easy DCP plugin also requires a separate license that you need to purchase from Fraunhofer IIS, the developer of the plugin.ĭavinci Resolve Studio 16 Easy DCP New Version 2018 Serial Key The serial key will be either a card with a code on it or a USB dongle that you need to plug into your computer. There are two ways to get a serial key for DaVinci Resolve Studio 16: either by purchasing it online or by getting it bundled with a Blackmagic Design camera. However, to use DaVinci Resolve Studio 16 and Easy DCP, you need to activate them with a valid serial key. DCPs are the standard format for delivering movies to cinemas, and with Easy DCP, you can create your own DCPs from within DaVinci Resolve Studio. One of the features that sets DaVinci Resolve Studio apart from other video editors is the ability to create and export Digital Cinema Packages (DCPs) using the Easy DCP plugin. How to Activate DaVinci Resolve Studio 16 with Easy DCPĭaVinci Resolve Studio 16 is a powerful video editing software that offers a range of features and tools for professional filmmakers, colorists, and post-production artists. In the aftermath of the D-Reaper incident, Hypnos changes its views on how to deal with Wild One appearances. Since Hypnos is a government agency, Yamaki reports to four officials, presumably his superiors in the Japanese government, and to the Chief Cabinet Secretary. Also at Hypnos's disposal are unmarked black vans and helicopters, used for investigation and combating Digimon. The agency employs scientists, operators, and computer programmers, as well as several field agents. Hypnos is covertly headquartered in the Tokyo Metropolitan Government Building, which also houses the Hypnos computer system, as well as several labs for research. Hypnos later helps in the battle against the D-Reaper by providing space and technology. Eventually, their efforts allow the children and their Digimon to return to the Real World. This new realization comes after Hypnos's leadership realizes that not all the Digimon are evil. In their efforts to better understand and defeat the Digimon, Hypnos recruits the computer programmers who originally made the Digimon, the Monster Makers, and attempts to use their knowledge to create a successful anti-Digimon weapon.Īfter the Tamers enter the Digital World, Hypnos's objectives change: they now seek only to bring the kids home. As time went on, they develop new and better methods of attacking Digimon, but these techniques are ineffective against the Deva. However, their efforts at first prove unsuccessful. Apparently Mitsuo Yamaki, the head of Hypnos, had an agenda to eliminate Digimon once and for all. Another function of the agency is to prevent media leaks about Digimon, as well as cover up incidents (such as creating cover stories) that involve Digimon. If a Digimon does manage to cross over, Hypnos would try to capture the Wild One and study it. ![]() As a result, the agency's new objective is to detect Digimon when they Bio-Emerge in the real world and to prevent it if possible. However, Hypnos discovered Digimon (termed "Wild Ones") who entered the real world. ![]() Because of the legal issues of violating privacy, Hypnos was kept secret from the public. Hypnos's original purpose was to monitor electronic communications of half the Earth for the Japanese government. Nimble Robotics was founded by former Stanford Ph.D. The funding will speed up the company’s hiring plans, scaling of robot deployment, and further product development. For mediaĪ set of high-resolution photos and raw videos of the DelFly Nimble, released under the CC BY-SA 4.0 license, can be downloaded here: photos, videos.Nimble Robotics, a warehouse automation company, has raised $50 million in its Series A funding led by DNS Capital and GSR Ventures. de Croon : A tailless aerial robotic flapper reveals that flies use torque coupling in rapid banked turns. At the same time, the high agility, combined with the programmability of the robot, opens up a new way of studying insect flight dynamics and control during high agility maneuvers, such as rapid banked turns observed in fruit-flies when evading predators. ![]() The so far unmatched combination of performances makes the lightweight (and thus inherently safe) natural-looking robot ready for many real-world tasks. Due to the lack of a tail, which provided passive stability in the previous designs, the robot relies on active stabilization, enabled by the onboard autopilot (STM32 microcontroller, MPU6000 6DOF IMU) and Paparazzi UAV software. Finally, yawing is achieved by actuating the roots of the left and right wing pairs such that their respective wingbeat-average thrust forces are tilted in opposite directions, creating torque around the yaw axis. Pitch torque is produced by adjusting the dihedral angle (central line of the flapping wings), which shifts the wingbeat-average thrust vectors of the two wing pairs forward or backward, with respect to the center of mass. Rolling is achieved by driving the two wing pairs at different flapping frequencies, which results in a thrust difference creating the torque around the roll axis. These are complemented with two rotary servo actuators, one adjusting the dihedral angle by changing the relative orientation of the two flapping mechanisms, and the other actuating the tips of the left and right wing-pair roots. To this end, the robot is equipped with two, independent, flapping mechanisms, one for each wing pair on the sides of the robot. To control the body orientation (attitude), the robot needs to be able to produce torques around the three orthogonal body axes. Like in quadrotors or helicopters, but also like in insects, forward/backward and sideways flight is achieved by pitching and rolling the robot’s body into the respective direction. ![]() At full throttle, the robot reaches a top speed of 7 m/s (~25 km/h). a camera system with a live video feed, additional sensors, etc.). The exceptional agility can be demonstrated by 360-degree flips around the pitch or roll axes or rapid transitions from hover to forward or sideways flight, and vice versa. The robot has a thrust-to-weight ratio of more than 1.3 and is capable of carrying an additional payload of up to 4 grams (e.g. ![]() This is thanks to design optimizations carried out with its tailed predecessor, the DelFly II, from which the flapping mechanism and wings were inherited. 3 m/s (~11 km/h) and enables a flight range of more than 1 kilometer. Its outstanding power efficiency peaks at a forward cruise speed of approx. At hover, the 29-g and 33-cm wingspan robot can fly for more than 5 minutes on a fully charged battery, while its 14 cm wings flap at a frequency of approx. ![]() From customization to logo embossment and even incorporating trendy designs-we will help you fulfill your private label clothing dreams. We are one of the Top-Rated Private Label Clothing Manufacturers in USAīusiness owners who are in the need of bulk private label stock for their business can consult the creative team of the sports bra suppliers. 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If you have an iOS device, and your card is registered to your Apple Wallet, Apple Pay will automatically display as a payment option within the McDonald’s app. Payment cards registered must be issued by a U.S. You can register Visa, MasterCard, American Express and Discover cards in the app. If not, "Order Here" will appear muted out, indicating that Mobile Order & Pay is not enabled at that location. If the restaurant is participating, "Order Here" will appear in black letters at the bottom of the detail page, allowing you to select it and begin the order. Within the location map, after selecting a restaurant icon, selecting the white detail box will also indicate if Mobile Order & Pay is available at a particular location. Mobile Order & Pay will appear in the McDonald's app as a feature when you're within 5 miles of a McDonald's restaurant that offers Mobile Order & Pay. ![]() Make sure you turn on location services so that we can show you all of the available features in the McDonald's app. Mobile Order & Pay How do I know which restaurants are participating in Mobile Order & Pay? You can also open your DoorDash, Grubhub, or Postmates apps to learn if there is a McDonald's location near you to browse menu items to order. For food item availability, please select McDelivery in the McDonald's app and view items available for delivery on Uber Eats in the app by selecting 'Order' on the bottom menu bar. How do I know what items are available for McDelivery? Enter your desired delivery address and you will be notified if McDelivery is available to you through our app. Select 'Order' from the bottom menu bar and switch from 'Pickup' to 'McDelivery'. To order McDelivery through the McDonald's app, log in, if you are not already. Uber Eats is also available to order from the McDonald's app. How do I know if McDelivery is available to my address?ĭepending on where you are, McDelivery is available on DoorDash, Uber Eats, Grubhub, or Postmates apps. ![]() One option you can consider is talking to your employer about the cost of the certification exam. So, a minimal investment now will pay off in the future as you continue to increase your earning potential. However, to put it in perspective, PMI estimates that project managers who have their certification make about 20 percent more than their peers without a certification. Obviously these costs may vary based on your training choices, but overall this is the amount you can expect to pay. PMP Certification Cost How Much Does Maintaining Your PMP Certification Cost?Īfter an in-depth look at the costs associated with earning your PMP certification, it’s time to ask the big question: is earning your PMP certification worth the cost? In total, you could be facing a cost of about $2,400 to $2,500. Think of this as an insurance policy on your investment in PMP training. Training providers that do this demonstrates both confidence in their course and how well they are able to prepare PMP certification candidates. Project Management Academy, for example, offers a 100 percent refund if you fail to pass your PMP exam. Top PMP training partners will help you with the audit, which saves you the time and the inconvenience of managing an audit yourself.Ī top training provider will also help protect your investment from another perspective – a money-back guarantee. PMI has the right to audit your materials at any time, which makes it important that your training provider choice is the right one. When you apply to take the PMP exam, you must show proof that you completed the training requirements. To ensure that you’re making a sound investment in your PMP training, you should work with a reputable training provider. ![]() While 35 hours seems like a lot of training, you’ll leave these sessions having fulfilled your training requirements and also feeling prepared to sit for your PMP exam. Although there is some work to do to maintain your PMP certification, this initial training cost is likely the highest PMP-related cost you’ll have to pay.įrom a time perspective, you can expect to spend about an hour for every project management education earned (around 35 hours in total). These training courses generally cost around $2,000. To be eligible for the exam, you must earn 35 hours of project management education OR CAPM certification. First, let’s look at what the training requirements entail. PMP exam training requires an investment as well, both in terms of PMP certification requirements and time commitment. |
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